Medicine and Health

SARS-CoV2-mediated suppression of NRF2-signaling reveals potent antiviral and anti-inflammatory activity of 4-octyl-itaconate and dimethyl fumarate

D. Olagnier

This groundbreaking research by David Olagnier reveals how NRF2 agonists, like 4-octyl-itaconate and dimethyl fumarate, significantly inhibit SARS-CoV-2 replication and show potential as broad-spectrum antiviral and anti-inflammatory agents for COVID-19 treatment.

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Playback language: English

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Abstract

This study demonstrates that the NRF2 antioxidant gene expression pathway is suppressed in COVID-19 patients. NRF2 agonists, 4-octyl-itaconate (4-OI) and dimethyl fumarate (DMF), inhibit SARS-CoV-2 replication across various cell lines. This antiviral effect extends to other viruses like HSV-1, HSV-2, Vaccinia, and Zika, through a type I interferon (IFN)-independent mechanism. 4-OI and DMF also limit inflammatory responses to SARS-CoV-2 infection. Therefore, NRF2 agonists show promise as broad-spectrum antiviral and anti-inflammatory agents, with DMF potentially repurposed for COVID-19 treatment.

Publisher

Nature Communications

Published On

Oct 20, 2020

Authors

David Olagnier

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