This study developed highly sensitive SARS-CoV-2-specific antibody and neutralization assays. All PCR+ subjects (n=115) showed SARS-CoV-2 Spike or Nucleocapsid protein-specific IgG antibodies, while negative controls did not. Neutralization was observed in COVID-19 and convalescent plasma. Hospitalized patients had significantly higher antibody and neutralization titers than outpatients or convalescent plasma donors. Some COVID-19 patients also had neutralizing antibodies against SARS-CoV. The assays' high specificity and sensitivity could improve understanding of the antibody response in COVID-19 and vaccine effectiveness.
Publisher
Communications Biology
Published On
Jan 29, 2021
Authors
Mikail Dogan, Lina Kozhaya, Lindsey Placek, Courtney Gunter, Mesut Yigit, Rachel Hardy, Matthew Plassmeyer, Paige Coatney, Kimberleigh Lillard, Zaheer Bukhari, Michael Kleinberg, Chelsea Hayes, Moshe Arditi, Ellen Klapper, Noah Merin, Bruce Tsan-Tang Liang, Raavi Gupta, Oral Alpan, Derya Unutmaz
Tags
SARS-CoV-2
antibodies
neutralization assays
COVID-19
vaccine effectiveness
serology
hospitalized patients
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