Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus causing severe outbreaks. A four-segmented RVFV (RVFV-4s) vaccine candidate (vRVFV-4s) was developed and shown to be completely avirulent in previous studies. This study demonstrates that vRVFV-4s does not disseminate in vaccinated animals, is not shed, does not revert to virulence, and induces protective immunity against homologous and heterologous RVFV challenge in lambs, goats, and calves after a single vaccination.
Publisher
npj Vaccines
Published On
Jul 24, 2020
Authors
Paul J. Wichgers Schreur, Nadia Oreshkova, Lucien van Keulen, Jet Kant, Sandra van de Water, Pál Soós, Yves Dehon, Anna Kollár, Zoltán Pénzes, Jeroen Kortekaas
Tags
Rift Valley fever virus
Vaccine
Avirulent
Immunity
Veterinary
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