Medicine and Health

Synthetic virology approaches to improve the safety and efficacy of oncolytic virus therapies

T. Azad, R. Rezaei, et al.

This exciting research conducted by Taha Azad, Reza Rezaei, and their colleagues explores innovative synthetic virology techniques that enhance the safety and efficacy of oncolytic virus therapies. By applying drug-controlled gene switches and synthetic promoters, the team successfully regulates viral replication and transgene expression, paving the way for safer cancer treatments.

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Abstract

This research paper explores synthetic virology approaches to enhance the safety and efficacy of oncolytic virus therapies. The authors adapt drug-controlled gene switches to control viral replication and transgene expression in vaccinia virus vectors. They rationally design synthetic promoters for robust inducible expression and generate chimeric synthetic promoters for additional regulatory layers. These systems are applied to modulate transgene expression, enabling precise control of oncolytic virus behavior, ultimately improving safety and efficacy in vivo.

Publisher

Nature Communications

Published On

May 26, 2023

Authors

Taha Azad, Reza Rezaei, Ragunath Singaravelu, Adrian Pelin, Stephen Boulton, Julia Petryk, Kemal Alper Onsu, Nikolas T. Martin, Victoria Hoskin, Mina Ghahremani, Marie Marotel, Ricardo Marius, Xiaohong He, Mathieu J. F. Crupi, Huy-Dung Hoang, Abdolrafat Nik-Aktar, Mahsa Ahmad, Nika Kooshki Zamani, Ashkan Golshani, Tommy Alain, Peter Greer, Michele Ardolino, Bryan C. Dickinson, Lee-Hwa Tai, Carolina S. Ilkow, John C. Bell

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