Veterinary Science

Safety and efficacy of four-segmented Rift Valley fever virus in young sheep, goats and cattle

P. J. W. Schreur, N. Oreshkova, et al.

Discover groundbreaking research on Rift Valley fever virus (RVFV), where the developed RVFV-4s vaccine candidate is shown to be completely avirulent and induces protective immunity in various animals. This essential study was conducted by leading experts including Paul J. Wichgers Schreur and Nadia Oreshkova.

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Abstract

Rift Valley fever virus (RVFV) is a mosquito-borne bunyavirus causing severe outbreaks. A four-segmented RVFV (RVFV-4s) vaccine candidate (vRVFV-4s) was developed and shown to be completely avirulent in previous studies. This study demonstrates that vRVFV-4s does not disseminate in vaccinated animals, is not shed, does not revert to virulence, and induces protective immunity against homologous and heterologous RVFV challenge in lambs, goats, and calves after a single vaccination.

Publisher

npj Vaccines

Published On

Jul 24, 2020

Authors

Paul J. Wichgers Schreur, Nadia Oreshkova, Lucien van Keulen, Jet Kant, Sandra van de Water, Pál Soós, Yves Dehon, Anna Kollár, Zoltán Pénzes, Jeroen Kortekaas

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