Medicine and Health

Efficacy and safety analysis of TACE + sunitinib vs. sunitinib in the treatment of unresectable advanced renal cell carcinoma: a retrospective study

C. Zheng, H. Lu, et al.

This groundbreaking study by Chuansheng Zheng and colleagues highlights the superior efficacy and safety of combining transarterial chemoembolization (TACE) with sunitinib in treating advanced renal cell carcinoma, showcasing remarkable improvements in response rates and survival outcomes.

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Playback language: English

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Abstract

This retrospective study compared the efficacy and safety of transarterial chemoembolization (TACE) combined with sunitinib versus sunitinib alone in treating 98 patients with unresectable advanced renal cell carcinoma (RCC). The TACE + sunitinib group showed significantly higher objective response rate (ORR), disease control rate (DCR), and longer overall survival (OS) and progression-free survival (PFS) compared to the sunitinib-only group. While the TACE + sunitinib group experienced a higher incidence of abdominal pain, fever, and vomiting (post-embolization syndrome), the combination therapy was deemed safe and effective.

Publisher

BMC Cancer

Published On

Mar 20, 2023

Authors

Chuansheng Zheng, Haohao Lu, Qing Ye, Li Fan, Xiangwen Xia

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