ROS-activated CXCR2+ neutrophils recruited by CXCL1 delay

Index

Abstract

This study investigated the role of neutrophils in denervated skeletal muscle atrophy. Using intravital imaging, flow cytometry, and transcriptome analysis, the researchers demonstrated that reactive oxygen species (ROS) activate neutrophils after denervation, leading to their recruitment to the muscle tissue via CXCL1-mediated chemotaxis. These CXCR2+ neutrophils delay atrophy before undergoing P53-mediated apoptosis within a week. The findings suggest neutrophils are a potential therapeutic target for denervated muscle atrophy.

Publisher

Experimental & Molecular Medicine

Published On

Jul 21, 2022

Authors

Yaoxian Xiang, Junxi Dai, Yao Li, Zongqi You, Junpeng Zhang, Xinying Huang, Shuqi Nie, Yujie Chen, Lei Xu, Fengming Liu, Junjian Jiang, Jianguang Xu

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