Mathematics

Quantifying in vitro B. anthracis growth and PA production and decay: a mathematical modelling approach

B. Williams, J. Paterson, et al.

This study by Bevelynn Williams and colleagues delves into the dynamics of protective antigen production and degradation by Bacillus anthracis, employing mathematical modeling and Bayesian techniques to shed light on toxin dynamics and implications for anthrax infection management.

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Playback language: English

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Abstract

This study quantifies protective antigen (PA) production and degradation by Bacillus anthracis using mathematical modeling and Bayesian statistical techniques. New experimental data, along with two published datasets, were used to calibrate a delay differential equation (DDE) model. The model distinguishes between natural PA decay and protease-mediated decay, showing promising consistency between datasets for most parameter estimates. This quantitative characterization of PA dynamics contributes to future mechanistic models of anthrax infection, incorporating toxin dynamics, immune response, and anti-toxin treatments.

Publisher

npj Systems Biology and Applications

Published On

Mar 29, 2024

Authors

Bevelynn Williams, Jamie Paterson, Helena J. Rawsthorne-Manning, Polly-Anne Jeffrey, Joseph J. Gillard, Grant Lythe, Thomas R. Laws, Martín López-García

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