Medicine and Health

Quantifying ERK activity in response to inhibition of the BRAFV600E-MEK-ERK cascade using mathematical modelling

S. J. Hamis, Y. Kapelyukh, et al.

This research, conducted by Sara J. Hamis and colleagues, unveils a groundbreaking mathematical model that quantifies ERK activity in BRAFV600E-mutant melanoma. The study reveals how the combination of BRAF and MEK inhibitors synergistically impacts ERK activity and highlights factors contributing to drug resistance, paving the way for optimized treatment strategies.

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