logo
ResearchBunny Logo
Pre-clinical investigation of liquid sirolimus for local drug delivery

Engineering and Technology

Pre-clinical investigation of liquid sirolimus for local drug delivery

D. Douroumis, Z. Ruzsa, et al.

This groundbreaking pilot study reveals the feasibility of delivering liquid sirolimus directly into arterial segments using a benchtop bioreactor, showcasing innovative technology tested by Dennis Douroumis, Zoltan Ruzsa, Meagan Todd, Linda B Liu, Justin M Saul, Saami K Yazdani, and Matthias Bossard.

00:00
00:00
Playback language: English
Abstract
This pilot study investigated the feasibility of delivering liquid sirolimus into arterial segments using a benchtop peripheral artery bioreactor. Four drug delivery devices were tested using a fluorescently tagged liquid drug and an ex vivo porcine artery model. The Occlusion perfusion catheter (OPC) showed the greatest drug penetration. Ex vivo flow-circuit model results demonstrated successful liquid sirolimus delivery and retention at 1 and 24 hours post-delivery using the OPC. This study shows, for the first time, the potential for direct liquid sirolimus delivery to the arterial medial layer via a liquid delivery catheter.
Publisher
Frontiers in Cardiovascular Medicine
Published On
Sep 15, 2023
Authors
Dennis Douroumis, Zoltan Ruzsa, Meagan Todd, Linda B Liu, Justin M Saul, Saami K Yazdani, Matthias Bossard
Tags
sirolimus
drug delivery
bioreactor
porcine artery
catheter

Related Publications

Explore these studies to deepen your understanding of the subject.

Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges
Engineering and Technology

Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges

R. P. Singh, A. Natarajan, et al.

A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates
Medicine and Health

A comparative study of COVID-19 transcriptional signatures between clinical samples and preclinical cell models in the search for disease master regulators and drug repositioning candidates

H. Chapola, M. A. D. Bastiani, et al.

Structural basis for modulation of human Nav1.3 by clinical drug and selective antagonist
Medicine and Health

Structural basis for modulation of human Nav1.3 by clinical drug and selective antagonist

X. Li, F. Xu, et al.

Application of chemometrics for modeling and optimization of ultrasound-assisted dispersive liquid–liquid microextraction for the simultaneous determination of dyes
Chemistry

Application of chemometrics for modeling and optimization of ultrasound-assisted dispersive liquid–liquid microextraction for the simultaneous determination of dyes

S. Shojaei, S. Shojaei, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny