Medicine and Health

Appropriate exercise level attenuates gut dysbiosis and valeric acid increase to improve neuroplasticity and cognitive function after surgery in mice

Z. Lai, W. Shan, et al.

This cutting-edge research by Zhongmeng Lai and colleagues revealed that low-intensity exercise effectively combats postoperative cognitive dysfunction (POCD) in mice. By reducing gut microbiota alterations and neuroinflammation, exercise promotes cognitive recovery, showcasing its potential as a therapeutic strategy for enhancing brain health after surgery.

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Abstract

This study investigated the effects of exercise on postoperative cognitive dysfunction (POCD) in mice. Surgery induced learning and memory impairment, which was transferable via fecal transplantation. Low-intensity exercise attenuated these effects by reducing gut microbiota changes and valeric acid levels. Valeric acid, a gut microbiota product, worsened neuroinflammation and cognitive function. Exercise also reduced neuroinflammation, maintained astrocytes in the A2 phenotype, and improved neuroplasticity. These benefits were observed in both adult and aged mice, highlighting the potential of low-intensity exercise as a therapeutic strategy for POCD.

Publisher

Molecular Psychiatry

Published On

Oct 18, 2021

Authors

Zhongmeng Lai, Weiran Shan, Jun Li, Jia Min, Xianzhang Zeng, Zhiyi Zuo

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