Physical exercise mediates a cortical FMRP-mTOR pathway to | ResearchBunny

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Abstract

This study investigated the molecular mechanism of exercise-mediated anxiolysis in adolescent mice using a chronic restraint stress (CRS) model. Fourteen days of treadmill exercise maintained normal neural activity and axonal myelination in the medial prefrontal cortex (mPFC), preventing anxiety-like behaviors. Exercise activated the mTOR pathway in the mPFC, with upstream inhibition of Fragile X mental retardation protein (FMRP) expression via RNA methylation. In summary, treadmill exercise modulates the FMRP-mTOR pathway to improve stress resilience.

Publisher

Translational Psychiatry

Published On

Jan 19, 2023

Authors

Lan Yan, Mei Wang, Fengzhen Yang, Yajie Wang, Siqi Wang, Kwok-Fai So, Li Zhang

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