Phenethylamine in chlorella alleviates high-fat diet-induced

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Abstract

This study investigated the effects of chlorella water extract (WEC) and phenethylamine (PHA) on high-fat diet (HFD)-induced liver damage in mice. PHA significantly reduced lipid oxidation and liver damage without substantially decreasing lipid accumulation. WEC showed similar but less potent effects. Both WEC and PHA lowered methylglyoxal levels and increased glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein levels. The results suggest that methylglyoxal triggers lipid oxidation, leading to liver damage, and that WEC and PHA alleviate this damage by regulating methylglyoxal through GAPDH.

Publisher

npj Science of Food

Published On

Jul 23, 2021

Authors

Yifeng Zheng, Agustin Martin-Morales, Jing Wang, Masaki Fujishima, Eri Okumura, Kenji Sato

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