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Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal

Medicine and Health

Phenethylamine in chlorella alleviates high-fat diet-induced mouse liver damage by regulating generation of methylglyoxal

Y. Zheng, A. Martin-morales, et al.

Discover how chlorella water extract and phenethylamine combat liver damage caused by high-fat diets in mice. This exciting research, conducted by Yifeng Zheng, Agustin Martin-Morales, Jing Wang, Masaki Fujishima, Eri Okumura, and Kenji Sato, reveals potential protective mechanisms against lipid oxidation and suggests a novel approach to liver health.

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Playback language: English
Abstract
This study investigated the effects of chlorella water extract (WEC) and phenethylamine (PHA) on high-fat diet (HFD)-induced liver damage in mice. PHA significantly reduced lipid oxidation and liver damage without substantially decreasing lipid accumulation. WEC showed similar but less potent effects. Both WEC and PHA lowered methylglyoxal levels and increased glyceraldehyde 3-phosphate dehydrogenase (GAPDH) protein levels. The results suggest that methylglyoxal triggers lipid oxidation, leading to liver damage, and that WEC and PHA alleviate this damage by regulating methylglyoxal through GAPDH.
Publisher
npj Science of Food
Published On
Jul 23, 2021
Authors
Yifeng Zheng, Agustin Martin-Morales, Jing Wang, Masaki Fujishima, Eri Okumura, Kenji Sato
Tags
Chlorella
Phenethylamine
Liver damage
High-fat diet
Methylglyoxal
GAPDH
Lipid oxidation

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