This study introduces a novel organ-specific, scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. The device, combined with an advanced coil-antenna system and multiplexing strategy, enables low-cost, high-throughput functional mapping of peripheral neural circuits. Application to the vagus nerve revealed an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite, demonstrating the device's durability in harsh gastric conditions.

Woo Seok Kim, Sungcheol Hong, Milenka Gamero, Vivekanand Jeevakumar, Clay M. Smithhart, Theodore J. Price, Richard D. Palmiter, Carlos Campos, Sung Il Park