Medicine and Health

Microfluidic vortex focusing for high throughput synthesis of size-tunable liposomes

J. Y. Han, J. N. L. Fiandra, et al.

Discover a groundbreaking microfluidic vortex focusing technique that allows for the synthesis of liposomes with unparalleled size control and high production rates! This research, conducted by Jung Yeon Han, Joseph N. La Fiandra, and Don L. DeVoe, reveals how producing liposomes as small as 27 nm at rates exceeding 20 g/h could revolutionize nanomedicine.

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Abstract

Control over vesicle size during liposome synthesis is crucial for defining the pharmaceutical properties of liposomal nanomedicines. This paper describes a microfluidic vortex focusing (MVF) technique that generates liposomes with precisely controlled size and low size variance at high throughput. By adjusting buffer and lipid flow rates, liposomes as small as 27 nm were produced with mass production rates exceeding 20 g/h, offering a path toward production-scale liposome synthesis.

Publisher

Nature Communications

Published On

Nov 16, 2022

Authors

Jung Yeon Han, Joseph N. La Fiandra, Don L. DeVoe

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