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Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples

Medicine and Health

Four-dimensional trapped ion mobility spectrometry lipidomics for high throughput clinical profiling of human blood samples

R. Lerner, D. Baker, et al.

This study by Raissa Lerner and colleagues unveils a cutting-edge 4D TIMS lipidomics platform that revolutionizes clinical lipid profiling. With automated lipid extraction and high-throughput analysis capabilities, this platform promises consistent and reproducible lipid profiling across various blood matrices, paving the way for innovative clinical applications.

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Playback language: English
Abstract
This study presents a high-throughput 4D TIMS lipidomics platform for clinical profiling of circulatory lipids. Automated lipid extraction, combined with microflow reversed-phase UHPLC-TIMS-MS and PASEF, enables high-throughput analysis. A stringent 4D annotation strategy and TOF MS quantification using level-3 internal standards allow reproducible lipid profiling in NIST human plasma and serum. The platform is applied to profile intra-individual lipidome phenotypes in various blood matrices, demonstrating its utility for high-throughput clinical applications.
Publisher
Nature Communications
Published On
Feb 20, 2023
Authors
Raissa Lerner, Dhanwin Baker, Claudia Schwitter, Sarah Neuhaus, Tony Hauptmann, Julia M. Post, Stefan Kramer, Laura Bindila
Tags
lipidomics
4D TIMS
clinical profiling
high-throughput analysis
lipid extraction
NIST plasma
blood matrices

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