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Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

Medicine and Health

Organ-specific, multimodal, wireless optoelectronics for high-throughput phenotyping of peripheral neural pathways

W. S. Kim, S. Hong, et al.

This innovative study led by Woo Seok Kim and colleagues presents a groundbreaking multimodal, wireless optoelectronic device, promising precise optogenetic manipulations in vivo. Its unexpected findings on vagal sensory fibers and appetite suppression push the boundaries of our understanding, showcasing resilience even in challenging gastric environments.

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Playback language: English
Abstract
This study introduces a novel organ-specific, scalable, multimodal, wireless optoelectronic device for precise and chronic optogenetic manipulations in vivo. The device, combined with an advanced coil-antenna system and multiplexing strategy, enables low-cost, high-throughput functional mapping of peripheral neural circuits. Application to the vagus nerve revealed an unexpected role for stomach, non-stretch vagal sensory fibers in suppressing appetite, demonstrating the device's durability in harsh gastric conditions.
Publisher
Nature Communications
Published On
Jan 05, 2021
Authors
Woo Seok Kim, Sungcheol Hong, Milenka Gamero, Vivekanand Jeevakumar, Clay M. Smithhart, Theodore J. Price, Richard D. Palmiter, Carlos Campos, Sung Il Park
Tags
optoelectronic device
optogenetic manipulations
vagus nerve
appetite suppression
peripheral neural circuits
functional mapping
multimodal technology

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