Medicine and Health

Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision

Y. Li, Y. Jiang, et al.

Discover how Yueming Li, Ying Jiang, Lu Lan, Xiaowei Ge, Ran Cheng, Yuewei Zhan, Guo Chen, Linli Shi, Runyu Wang, Nan Zheng, Chen Yang, and Ji-Xin Cheng have revolutionized brain stimulation with their groundbreaking optically-generated focused ultrasound (OFUS) technology, achieving unmatched precision in neuromodulation. This innovative method could significantly enhance our understanding of brain function and treatment for neurological diseases.

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Abstract

High precision neuromodulation is crucial for understanding brain function and treating neurological diseases. Current non-invasive methods have limited precision. This paper introduces optically-generated focused ultrasound (OFUS) for non-invasive brain stimulation with ultrahigh precision. OFUS, generated by a soft optoacoustic pad (SOAP), achieves an ultrahigh lateral resolution of 83 µm, significantly surpassing conventional transcranial focused ultrasound (tFUS). Effective OFUS neuromodulation in vitro and submillimeter transcranial stimulation in vivo are demonstrated, requiring significantly less acoustic energy than tFUS. OFUS offers enhanced capabilities for neuroscience research and disease treatment.

Publisher

Light Science & Applications

Published On

Authors

Yueming Li, Ying Jiang, Lu Lan, Xiaowei Ge, Ran Cheng, Yuewei Zhan, Guo Chen, Linli Shi, Runyu Wang, Nan Zheng, Chen Yang, Ji-Xin Cheng

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