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Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

Medicine and Health

Oncolytic viruses engineered to enforce cholesterol efflux restore tumor-associated macrophage phagocytosis and anti-tumor immunity in glioblastoma

S. Wang, W. Yan, et al.

This groundbreaking research by Shiqun Wang, Wei Yan, and colleagues reveals how cholesterol metabolism in glioblastoma impairs antitumor immunity, leading to disease progression. By harnessing apolipoprotein A1, they not only restore phagocytosis in tumor-associated macrophages but also activate a long-lasting immune response, offering a potential immunometabolic therapy for this aggressive cancer.

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