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Abstract
This study investigated the association between retrospective reports of adversity during childhood or pregnancy and inflammatory imbalance in 53 low-income women exposed to interpersonal violence. Early life adversity (ELA) and pregnancy adversity (PA) were associated with higher M1/M2 gene expression (pro-inflammatory), while total lifetime adversity (TLA) was associated with lower M1/M2 gene expression. These findings suggest distinct immunological impacts of adversity timing, highlighting the importance of considering sensitive periods in understanding the effects of adversity on health.
Publisher
Translational Psychiatry
Published On
Jul 20, 2021
Authors
Kirstin Abchabcher, Melissa Hagman, Iris M. Steine, Luisa Rivera, Steve Cole, Alyssa Baccarella, Elissa S. Epel, Alicia Lieberman, Nicole R. Bush
Tags
early life adversity
pregnancy adversity
inflammatory imbalance
interpersonal violence
gene expression
health effects

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