Medicine and Health

Adversity in early life and pregnancy are immunologically distinct from total life adversity: macrophage-associated phenotypes in women exposed to interpersonal violence

K. Abchabcher, M. Hagman, et al.

This groundbreaking research by Kirstin Abchabcher and colleagues reveals how early life and pregnancy adversities can lead to different immunological responses in low-income women exposed to interpersonal violence. Discover the intriguing connections between childhood trauma and inflammation in this essential study.

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Abstract

This study investigated the association between retrospective reports of adversity during childhood or pregnancy and inflammatory imbalance in 53 low-income women exposed to interpersonal violence. Early life adversity (ELA) and pregnancy adversity (PA) were associated with higher M1/M2 gene expression (pro-inflammatory), while total lifetime adversity (TLA) was associated with lower M1/M2 gene expression. These findings suggest distinct immunological impacts of adversity timing, highlighting the importance of considering sensitive periods in understanding the effects of adversity on health.

Publisher

Translational Psychiatry

Published On

Jul 20, 2021

Authors

Kirstin Abchabcher, Melissa Hagman, Iris M. Steine, Luisa Rivera, Steve Cole, Alyssa Baccarella, Elissa S. Epel, Alicia Lieberman, Nicole R. Bush

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