Medicine and HealthNature Communications
Omicron subvariant BA.5 efficiently infects lung cells
M. Hoffmann, L. R. Wong, et al.
This groundbreaking research by Markus Hoffmann and colleagues reveals that the dominant Omicron subvariant BA.5 exhibits increased lung cell infection capabilities compared to its predecessors BA.1 and BA.2. With enhanced spike protein cleavage and efficient receptor recognition in polarized lung cells, BA.5 shows a surprising reversal of attenuation, raising concerns about its potential link to severe disease.
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