Chemistry
Nucleophilic trifluoromethoxylation of alkyl halides without silver
Y. Li, Y. Yang, et al.
This groundbreaking research by Yan Li, Yang Yang, Jinrui Xin, and Pingping Tang introduces a novel nucleophilic trifluoromethoxylation method for alkyl halides using (E)-O-trifluoromethyl-benzaldoximes (TFBO) as a reagent. This approach offers a practical solution to preparing molecules with the trifluoromethoxy group, essential for pharmaceuticals and agrochemicals, under mild conditions and without silver, showcasing impressive functional group compatibility.
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