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Non-antibiotic pharmaceuticals are toxic against *Escherichia coli* with no evolution of cross-resistance to antibiotics

Medicine and Health

Non-antibiotic pharmaceuticals are toxic against *Escherichia coli* with no evolution of cross-resistance to antibiotics

R. J. Hall, A. E. Snaith, et al.

Explore the pressing issue of antimicrobial resistance in this groundbreaking study by Rebecca J. Hall and her colleagues, revealing how long-term exposure to non-antibiotic pharmaceuticals impacts *E. coli* without fostering antibiotic cross-resistance. Dive into their findings on the effects of common drugs like ibuprofen and metformin.

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Playback language: English
Abstract
Antimicrobial resistance is a global concern, exacerbated by pharmaceutical plant effluent. This study investigated the toxicity of four non-antibiotic pharmaceuticals (acetaminophen, ibuprofen, propranolol, metformin) and titanium dioxide against *E. coli*, and whether long-term exposure selects for cross-resistance to antibiotics. All compounds reduced *E. coli* growth, with ibuprofen causing upregulation of stress response and multidrug efflux genes. However, 30-day exposure did not select for significant genetic changes or cross-resistance to antibiotics, suggesting these compounds, at environmentally relevant concentrations, do not select for antibiotic cross-resistance in *E. coli*.
Publisher
npj Antimicrobials & Resistance
Published On
Apr 15, 2024
Authors
Rebecca J. Hall, Ann E. Snaith, Sarah J. Element, Robert A. Moran, Hannah Smith, Elizabeth A. Cummins, Michael J. Bottery, Kaniz F. Chowdhury, Dipti Sareen, Iqbal Ahmad, Jessica M. A. Blair, Laura J. Carter, Alan McNally
Tags
antimicrobial resistance
pharmaceuticals
E. coli
cross-resistance
toxicity
environmental impact
drug exposure

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