Medicine and Health

N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo

J. A. Morales-garcia, J. Calleja-conde, et al.

This groundbreaking research by Jose A. Morales-Garcia and colleagues reveals the potential of N,N-dimethyltryptamine (DMT) in enhancing neurogenesis and cognitive function. The findings demonstrate that DMT activates the hippocampus, leading to improved memory performance and insights into adult neurogenesis. Discover how this fascinating compound could shape cognitive health!

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Playback language: English

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Abstract

This study investigated the neurogenic effects of N,N-dimethyltryptamine (DMT), a component of ayahuasca, in vitro and in vivo. Results showed that DMT administration activated the subgranular zone of the dentate gyrus in the hippocampus, promoting new neuron generation. Mice treated with DMT performed better in memory tests, suggesting functional relevance. The neurogenic effect involved sigma-1 receptor (S1R) activation, as an S1R antagonist blocked the effect. DMT treatment thus regulates neural stem cell proliferation and neuroblast migration, enhancing adult neurogenesis and cognitive function.

Publisher

Translational Psychiatry

Published On

Authors

Jose A. Morales-Garcia, Javier Calleja-Conde, Jose A. Lopez-Moreno, Sandra Alonso-Gil, Marina Sanz-SanCristobal, Jordi Riba, Ana Perez-Castillo

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