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New liposidomycin congeners produced by *Streptomyces* sp. TMPU-20A065, anti-*Mycobacterium avium* complex agents with therapeutic efficacy in a silkworm infection model

Medicine and Health

New liposidomycin congeners produced by *Streptomyces* sp. TMPU-20A065, anti-*Mycobacterium avium* complex agents with therapeutic efficacy in a silkworm infection model

A. Yagi, M. Fujiwara, et al.

Discover the potential of new liposidomycin congeners as anti-*Mycobacterium avium* complex agents! Researchers Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, and Ryuji Uchida have isolated three novel compounds, revealing exciting in vitro activities and promising therapeutic effects in a silkworm infection model.

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Playback language: English
Abstract
Three new liposidomycin congeners (1, 2, and 4), along with 14 known liposidomycins (3 and 5–17), were isolated from the culture broth of *Streptomyces* sp. TMPU-20A065 as anti-*Mycobacterium avium* complex agents. The structures were elucidated using NMR and MS. Compounds 1, 2, and 4 are type-I liposidomycins with sulfate groups and methylglutaric acid, each having a different acyl side chain. Compounds 1–17 showed *in vitro* anti-*M. avium* and *M. intracellulare* activity (MICs: 2.0–64 µg ml⁻¹). They also demonstrated potent therapeutic effects in a silkworm infection model (ED₅₀: 0.12–3.7 µg larva⁻¹ g⁻¹).
Publisher
The Journal of Antibiotics
Published On
May 08, 2024
Authors
Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, Ryuji Uchida
Tags
liposidomycin
anti-*Mycobacterium avium*
Streptomyces
in vitro activity
therapeutic effects
silkworm model
NMR and MS

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