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New liposidomycin congeners produced by *Streptomyces* sp. TMPU-20A065, anti-*Mycobacterium avium* complex agents with therapeutic efficacy in a silkworm infection model

Medicine and Health

New liposidomycin congeners produced by *Streptomyces* sp. TMPU-20A065, anti-*Mycobacterium avium* complex agents with therapeutic efficacy in a silkworm infection model

A. Yagi, M. Fujiwara, et al.

Discover the potential of new liposidomycin congeners as anti-*Mycobacterium avium* complex agents! Researchers Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, and Ryuji Uchida have isolated three novel compounds, revealing exciting in vitro activities and promising therapeutic effects in a silkworm infection model.... show more
Abstract
Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5–17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the structure. Compounds 1–17 exhibited in vitro anti-M. avium and M. intracellulare activities with MIC values ranging between 2.0 and 64 µg ml⁻¹. Furthermore, 1–17 exerted potent therapeutic effects in an in vivo-mimic silkworm infection model with ED₅₀ values ranging between 0.12 and 3.7 µg larva⁻¹ g⁻¹.
Publisher
The Journal of Antibiotics
Published On
May 08, 2024
Authors
Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, Ryuji Uchida
DOI
https://doi.org/10.1038/s41429-024-00724-4
Tags
liposidomycin
anti-*Mycobacterium avium*
Streptomyces
in vitro activity
therapeutic effects
silkworm model
NMR and MS

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