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New liposidomycin congeners produced by *Streptomyces* sp. TMPU-20A065, anti-*Mycobacterium avium* complex agents with therapeutic efficacy in a silkworm infection model
Medicine and HealthThe Journal of Antibiotics

New liposidomycin congeners produced by *Streptomyces* sp. TMPU-20A065, anti-*Mycobacterium avium* complex agents with therapeutic efficacy in a silkworm infection model

A. Yagi, M. Fujiwara, et al.

Discover the potential of new liposidomycin congeners as anti-*Mycobacterium avium* complex agents! Researchers Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, and Ryuji Uchida have isolated three novel compounds, revealing exciting in vitro activities and promising therapeutic effects in a silkworm infection model.... show more
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Abstract
Three new liposidomycin congeners (1, 2, and 4), together with 14 known liposidomycins (3 and 5–17), were isolated from the culture broth of Streptomyces sp. TMPU-20A065 as anti-Mycobacterium avium complex agents. The structures of liposidomycins were elucidated by spectroscopic analyses, including NMR and MS. Compounds 1, 2, and 4 belong to type-I liposidomycin-containing sulfate groups and methylglutaric acid, each with a different acyl side chain in the structure. Compounds 1–17 exhibited in vitro anti-M. avium and M. intracellulare activities with MIC values ranging between 2.0 and 64 µg ml⁻¹. Furthermore, 1–17 exerted potent therapeutic effects in an in vivo-mimic silkworm infection model with ED₅₀ values ranging between 0.12 and 3.7 µg larva⁻¹ g⁻¹.
Publisher
The Journal of Antibiotics
Published On
May 08, 2024
Authors
Akiho Yagi, Mayu Fujiwara, Mayu Sato, Yuzu Abe, Ryuji Uchida
DOI
https://doi.org/10.1038/s41429-024-00724-4
Tags
liposidomycinanti-*Mycobacterium avium*Streptomycesin vitro activitytherapeutic effectssilkworm modelNMR and MS
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