Medicine and Health

Neurotoxic amyloidogenic peptides in the proteome of SARS-CoV-2: potential implications for neurological symptoms in COVID-19

M. Charnley, S. Islam, et al.

In a groundbreaking study by Mirren Charnley and colleagues, new insights into COVID-19 reveal that amyloid formation from SARS-CoV-2 proteins could be linked to neurological symptoms experienced by some patients. This research highlights the crucial connection between viral proteins and their potential toxic effects on neuronal cells, paving the way for future investigations into COVID-19's neurological impact.

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Abstract

COVID-19, primarily a respiratory disease, often presents neurological symptoms in up to 30% of cases. This study investigates whether amyloid formation from SARS-CoV-2 proteins contributes to these neurological issues. Two peptides from the SARS-CoV-2 proteome (ORF6 and ORF10) were identified that self-assemble into amyloid structures and demonstrate high toxicity to neuronal cells. This suggests that amyloid aggregates of SARS-CoV-2 proteins might trigger neurological symptoms in COVID-19.

Publisher

Nature Communications

Published On

Jun 13, 2022

Authors

Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirdra, Julian Ratcliffe, Jiangtao Zhou, Raffaele Mezzenga, Mark D. Hulett, Kyunghoon Han, Joshua T. Berryman, Nicholas P. Reynolds

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