COVID-19, primarily a respiratory disease, often presents neurological symptoms in up to 30% of cases. This study investigates whether amyloid formation from SARS-CoV-2 proteins contributes to these neurological issues. Two peptides from the SARS-CoV-2 proteome (ORF6 and ORF10) were identified that self-assemble into amyloid structures and demonstrate high toxicity to neuronal cells. This suggests that amyloid aggregates of SARS-CoV-2 proteins might trigger neurological symptoms in COVID-19.
Publisher
Nature Communications
Published On
Jun 13, 2022
Authors
Mirren Charnley, Saba Islam, Guneet K. Bindra, Jeremy Engwirdra, Julian Ratcliffe, Jiangtao Zhou, Raffaele Mezzenga, Mark D. Hulett, Kyunghoon Han, Joshua T. Berryman, Nicholas P. Reynolds
Tags
COVID-19
neurological symptoms
amyloid formation
SARS-CoV-2
neuronal toxicity
proteins
self-assembly
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