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Abstract
Innate lymphoid cells (ILCs) are important immune regulators, but their precise tissue localization and microenvironmental interactions remain unclear. This study combines multiplexed immunofluorescence and a computational analysis pipeline to identify CD127+ ILCs *in situ*, characterize them, and define their microenvironments. The researchers identified IRF4 as a marker for tonsillar ILC3s and conserved stromal landmarks for ILC localization, revealing shared niches with plasma cells in the tonsil. This work provides a platform for multiparametric histological analysis of ILCs to advance ILC biology understanding.
Publisher
Nature Communications
Published On
Mar 19, 2021
Authors
Anna Pascual-Reguant, Ralf Köhler, Ronja Mothes, Sandy Bauherr, Daniela C. Hernández, Ralf Uecker, Karolin Holzwarth, Katja Kotsch, Maximilian Seidl, Lars Philipsen, Werner Müller, Chiara Romagnani, Raluca Niesner, Anja E. Hauser
Tags
Innate lymphoid cells
ILC3s
microenvironment
immunofluorescence
histological analysis
tonsil
IRF4

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