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Abstract
This randomized pilot study investigated MDMA-assisted psychotherapy for anxiety in individuals with life-threatening illnesses (LTIs). Participants (n=18) were randomized to receive MDMA (n=13) or placebo (n=5) with psychotherapy. The primary outcome, change in STAI-Trait scores, showed a greater reduction in the MDMA group (-23.5) compared to placebo (-8.8), but the difference wasn't statistically significant (p=.056). MDMA was well-tolerated. These preliminary findings suggest the potential of MDMA-assisted psychotherapy for LTI-related anxiety, warranting larger trials.
Publisher
Scientific Reports
Published On
Nov 24, 2020
Authors
Philip E. Wolfson, Julane Andries, Allison A. Feduccia, Lisa Jerome, Julie B. Wang, Emily Williams, Shannon C. Carlin, Evan Sola, Scott Hamilton, Berra Yazar-Klosinski, Amy Emerson, Michael C. Mithoefer, Rick Doblin
Tags
MDMA
psychotherapy
anxiety
life-threatening illnesses
pilot study
placebo
tolerance

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