logo
ResearchBunny Logo
Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

Medicine and Health

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

F. Wittlinger, B. C. Ogboo, et al.

This groundbreaking study unveiled a series of bivalent EGFR inhibitors, showcasing their remarkable ability to target both ATP and allosteric pockets with enhanced potency against drug-resistant mutants. Conducted by a dedicated team of researchers, their innovative linker design has opened new avenues in bivalent agent strategies, providing insights that may change the landscape of cancer treatment.

00:00
00:00
Playback language: English
Citation Metrics
Citations
0
Influential Citations
0
Reference Count
0

Note: The citation metrics presented here have been sourced from Semantic Scholar and OpenAlex.

Related Publications

Explore these studies to deepen your understanding of the subject.

Human antibodies to SARS-CoV-2 with a recurring YYDRXG motif retain binding and neutralization to variants of concern including Omicron
Medicine and Health

Human antibodies to SARS-CoV-2 with a recurring YYDRXG motif retain binding and neutralization to variants of concern including Omicron

H. Liu, C. I. Kaku, et al.

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes
Medicine and Health

A machine learning-based chemoproteomic approach to identify drug targets and binding sites in complex proteomes

I. Piazza, N. Beaton, et al.

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial
Medicine and Health

Efficacy of early PET-CT directed switch to carboplatin and paclitaxel based definitive chemoradiotherapy in patients with oesophageal cancer who have a poor early response to induction cisplatin and capecitabine in the UK: a multi-centre randomised controlled phase II trial

S. Mukherjee, C. N. Hurt, et al.

Surprising combinations of research contents and contexts are related to impact and emerge with scientific outsiders from distant disciplines
Interdisciplinary Studies

Surprising combinations of research contents and contexts are related to impact and emerge with scientific outsiders from distant disciplines

F. Shi and J. Evans

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny