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Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors
Medicine and HealthCommunications Chemistry

Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors

F. Wittlinger, B. C. Ogboo, et al.

This groundbreaking study unveiled a series of bivalent EGFR inhibitors, showcasing their remarkable ability to target both ATP and allosteric pockets with enhanced potency against drug-resistant mutants. Conducted by a dedicated team of researchers, their innovative linker design has opened new avenues in bivalent agent strategies, providing insights that may change the landscape of cancer treatment.... show more
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