Chemistry

Iridium-catalyzed enantioselective synthesis of chiral γ-amino alcohols and intermediates of (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine

C. Liu, L. Zhang, et al.

Discover how researchers Chengyu Liu and colleagues have designed innovative tridentate ferrocene-based phosphine ligands that enable iridium-catalyzed asymmetric hydrogenation of β-amino ketones, creating a pathway for the industrial production of valuable chiral γ-amino alcohols, including (S)-duloxetine and (R)-fluoxetine.