Iridium-catalyzed enantioselective synthesis of chiral γ-amino | ResearchBunny

Index

Abstract

Chiral γ-amino alcohols are prevalent structural motifs in pharmaceuticals. This paper details the design, synthesis, and evaluation of tridentate ferrocene-based phosphine ligands for iridium-catalyzed asymmetric hydrogenation of β-amino ketones, yielding diverse chiral γ-amino alcohols with high yields and enantioselectivities. Gram-scale reactions demonstrate the potential for industrial synthesis of chiral drugs like (S)-duloxetine, (R)-fluoxetine, and (R)-atomoxetine.

Publisher

Communications Chemistry

Published On

May 19, 2022

Authors

Chengyu Liu, Lei Zhang, Liming Cao, Yan Xiong, Yueyue Ma, Ruihua Cheng, Jinxing Ye

Related Publications

Explore these studies to deepen your understanding of the subject.

Political Science

M. R. Kukrit Pramoj's theory of good governance and political change: the dialectics of Farang Sakdina

T. Waters

Chemistry

Expedited synthesis of α-amino acids by single-step enantioselective α-amination of carboxylic acids

C. Ye, D. R. Dansby, et al.

Chemistry

Visible-light-mediated catalyst-free synthesis of unnatural α-amino acids and peptide macrocycles

M. Wang, C. Wang, et al.

Chemistry

Nickel catalyzed multicomponent stereodivergent synthesis of olefins enabled by electrochemistry, photocatalysis and photo-electrochemistry

C. Zhu, H. Yue, et al.

Listen, Learn & Level Up

Over 10,000 hours of research content in 25+ fields, available in 12+ languages.

No more digging through PDFs—just hit play and absorb the world's latest research in your language, on your time.

listen to research audio papers with researchbunny