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Abstract
This research presents a novel approach that integrates digital pathology and mathematical modeling to optimize the timing of on-treatment biopsies in cancer immunotherapy clinical trials. Using digitized biopsies from a clinical trial of Simlukafusp, an immunomodulatory molecule, the researchers developed and validated an agent-based model that accurately predicts the spatial dynamics of immune cells. The model's predictive capabilities extend to designing phase 1-2 study protocols, conceiving combination therapies, and personalizing healthcare.
Publisher
npj Digital Medicine
Published On
Jul 12, 2022
Authors
L. G. Hutchinson, O. Grimm
Tags
digital pathology
cancer immunotherapy
biopsies
agent-based model
immune cells
personalized healthcare
clinical trials

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