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Inference of person-to-person transmission of COVID-19 reveals hidden super-spreading events during the early outbreak phase

Medicine and Health

Inference of person-to-person transmission of COVID-19 reveals hidden super-spreading events during the early outbreak phase

L. Wang, X. Didelot, et al.

This groundbreaking study by Liang Wang, Xavier Didelot, and colleagues delves into the early COVID-19 outbreak in China, revealing fascinating insights into SARS-CoV-2 transmission dynamics. By analyzing 208 genome sequences, the researchers uncovered compelling evidence of super-spreading events, confirming their crucial role in the virus's rapid spread during the pandemic's inception.

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Playback language: English
Abstract
This study analyzes 208 SARS-CoV-2 genome sequences from the early COVID-19 outbreak in China. Using phylogenetic analysis and Bayesian inference, the researchers reconstructed person-to-person transmission, finding evidence of super-spreading events (SSEs) characterized by individuals infecting a disproportionately large number of others. The dispersion parameter of the offspring distribution (0.23) indicated significant overdispersion, confirming the substantial role of SSEs in the early pandemic spread.
Publisher
Nature Communications
Published On
Jan 01, 2021
Authors
Liang Wang, Xavier Didelot, Jing Yang, Gary Wong, Yi Shi, Wenjun Liu, George F. Gao, Yuhai Bi
Tags
SARS-CoV-2
COVID-19
phylogenetic analysis
super-spreading events
transmission dynamics
genome sequences
overdispersion

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