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In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors

Physics

In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors

Z. Qin, Z. Wang, et al.

Discover the groundbreaking research by Zhuoyang Qin and colleagues on zero-field EPR spectroscopy utilizing nanodiamonds to unravel molecular dynamics in living cells. This innovative approach presents robust spectra that promise to transform *in vivo* EPR analysis.

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Playback language: English
Abstract
Electron paramagnetic resonance (EPR) spectroscopy's ultimate goal is to analyze molecular dynamics in situ, such as within a living cell. Nanodiamonds (NDs) hosting nitrogen-vacancy (NV) centers are promising EPR sensors for this goal. However, ND-based EPR spectroscopy has been elusive due to challenges in controlling NV centers with undefined orientations within flexible NDs. This research presents a generalized zero-field EPR technique with orientation-robust spectra, achieved by applying amplitude modulation to the control field, generating equidistant Floquet states with orientation-independent energy splitting at the modulation frequency. Zero-field EPR spectra of vanadyl ions in aqueous glycerol solution with embedded single NDs were acquired, advancing *in vivo* EPR.
Publisher
Nature Communications
Published On
Oct 07, 2023
Authors
Zhuoyang Qin, Zhecheng Wang, Fei Kong, Jia Su, Zhehua Huang, Pengju Zhao, Sanyou Chen, Qi Zhang, Fazhan Shi, Jiangfeng Du
Tags
electron paramagnetic resonance
nanodiamonds
zero-field EPR
molecular dynamics
in vivo EPR
amplitude modulation
Floquet states

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