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Abstract
Type 2 diabetes (T2D) significantly increases heart failure risk, often showing cardiovascular abnormalities before symptoms. This study investigated the impact of T2D remission on cardiovascular structure and function, exercise capacity, and risk profile. Adults with T2D without cardiovascular disease underwent cardiovascular imaging, cardiopulmonary exercise testing, and cardiometabolic profiling. T2D remission cases (HbA1c < 6.5% without glucose-lowering therapy for ≥3 months) were propensity score matched to those with active T2D and non-T2D controls. T2D remission was linked to a better metabolic risk profile and ventilatory response to exercise but not to improvements in cardiovascular structure or function. Concentric remodeling persisted in remission. Continued risk factor control is crucial for this patient group.
Publisher
Journal of Cardiovascular Development and Disease
Published On
Apr 24, 2023
Authors
Joanna M Bilak, Jian L Yeo, Gaur S Gulsin, Anna-Marie Marsh, Manjit Sian, Abhishek Datta, Sarah L Ayton, Kelly S Parke, Moira Bain, Wenjie Pang, Sherif Boulos, Tim G St Pierre, Melanie J Davies, Thomas Yates, Gerry P Mccann, Emer M Brady
Tags
Type 2 diabetes
heart failure
cardiovascular imaging
exercise capacity
metabolic risk profile
remission

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