mRNA SARS-CoV-2 vaccines, while generally safe and effective, can elicit poor immunogenic responses in immunocompromised individuals, including people living with HIV (PLWH). This study investigated whether baseline gut microbiota predicts immune responses to the BNT162b2 mRNA SARS-CoV-2 vaccine in healthy controls and PLWH. Individuals with high spike IgG titers and high spike-specific CD4⁺ T-cell responses showed low gut α-diversity. *Bifidobacterium* and *Faecalibacterium* were associated with higher spike IgG titers, while *Cloacibacillus* was associated with lower titers. The findings suggest that microbiome modulation could optimize SARS-CoV-2 mRNA vaccine immunogenicity.
Publisher
npj Biofilms and Microbiomes
Published On
Dec 20, 2023
Authors
Shilpa Ray, Aswathy Narayanan, Jan Vesterbacka, Ola Blennow, Puran Chen, Yu Gao, Giorgio Gabarrini, Hans-Gustaf Ljunggren, Marcus Buggert, Lokeshwaran Manoharan, Margaret Sällberg Chen, Soo Aleman, Anders Sönnerborg, Piotr Nowak
