Medicine and Health

Impact of Severe Acute Respiratory Syndrome Coronavirus 2 Variants on Short-and Mid-term Cardiac Outcomes in Multisystem Inflammatory Syndrome in Children

S. Pinninti, C. Hebson, et al.

Explore the promising cardiac outcomes in children affected by Multisystem Inflammatory Syndrome (MIS-C) post-SARS-CoV-2 infection, as revealed in a study conducted by Swetha Pinninti, Camden Hebson, and colleagues. Most children experienced normalization of cardiac abnormalities within 5-6 weeks, regardless of the viral variant. Discover the insights that can shape future pediatric care.

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Abstract

Multisystem inflammatory syndrome in children (MIS-C) is a hyper-inflammatory condition associated with SARS-CoV-2 infection. This study investigated the acute cardiac involvement and short-and mid-term cardiac outcomes in children with MIS-C following three different waves of SARS-CoV-2 infection. 131 children were divided into three groups based on the timing of their hospitalization, corresponding to the prevalence of Wuhan, Alpha, and Delta variants. The study found favorable cardiac outcomes with normalization of laboratory, ECG, and ECHO abnormalities in most children within 5-6 weeks following MIS-C, regardless of the infecting SARS-CoV-2 variant. While there were some initial abnormalities, these largely resolved, and significant differences between the groups were not observed.

Publisher

Open Forum Infectious Diseases

Published On

Mar 08, 2024

Authors

Swetha Pinninti, Camden Hebson, Jacqueline Collins, Connie Trieu, Sushma Boppana, Markus Buchfellner, Cathy Seripin, April Yarbrough, Claudette Poole, Shannon Ross, Scott James, Cecelia Hutto, Suresh Boppana

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