logo
ResearchBunny Logo
Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

Health and Fitness

Impact of aging and exercise on skeletal muscle mitochondrial capacity, energy metabolism, and physical function

L. Grevendonk, N. J. Connell, et al.

This study explores how aging affects skeletal muscle mitochondrial function and health, revealing that regular exercise can significantly combat age-related declines. Conducted by a team of researchers including L. Grevendonk and N. J. Connell, the findings emphasize the vital role of physical activity in maintaining mitochondrial capacity and overall muscle health.

00:00
Playback language: English
Abstract
This study investigated the impact of aging and physical activity on skeletal muscle mitochondrial function and overall health. Researchers compared young and older adults with similar habitual physical activity levels, as well as exercise-trained older adults and physically impaired older adults. Aging was linked to decreased mitochondrial capacity, exercise capacity, muscle function, and insulin sensitivity, even with sufficient daily activity. Regular exercise training largely counteracted these age-related declines. Mitochondrial capacity correlated with exercise efficiency and insulin sensitivity, supporting a connection between mitochondrial function and age-related muscle deterioration.
Publisher
Nature Communications
Published On
Aug 06, 2021
Authors
L. Grevendonk, N. J. Connell, C. McCrum, C. E. Fealy, L. Bilet, Y. M. H. Bruls, J. Mevenkamp, V. B. Schrauwen-Hinderling, J. A. Jörgensen, E. Moonen-Kornips, G. Schaart, B. Havekes, J. de Vogel-van den Bosch, M. C. E. Bragt, K. Meijer, P. Schrauwen, J. Hoeks
Tags
aging
physical activity
skeletal muscle
mitochondrial function
exercise training
insulin sensitivity
health
Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny