logo
ResearchBunny Logo
Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

Medicine and Health

Immunologic mechanisms of seasonal influenza vaccination administered by microneedle patch from a randomized phase I trial

N. G. Rouphael, L. Lai, et al.

This exciting phase 1 clinical trial, conducted by renowned researchers including Nadine G. Rouphael and Mark J. Mulligan, showcases the safety and superior immunogenic response of inactivated influenza virus vaccines delivered via dissolvable microneedle patches compared to traditional intramuscular injections. Discover how innovative delivery methods might revolutionize flu vaccination!

00:00
00:00
Playback language: English
Abstract
This phase 1 randomized, single-center clinical trial evaluated the safety and immunogenicity of inactivated influenza virus vaccine delivered via dissolvable microneedle patches (MNPs). Comparing humoral and cellular responses in participants receiving vaccination by MNP versus intramuscular (IM) injection, researchers found similar hemagglutination inhibition (HAI) titers and antibody avidity, despite a lower antigen dose in the MNP group. MNPs, however, generated higher neuraminidase inhibition (NAI) titers and a larger percentage of circulating T follicular helper cells than IM vaccination. The study concludes that MNP delivery produces comparable or superior humoral and cellular immune responses to IM injection.
Publisher
npj Vaccines
Published On
Jul 14, 2021
Authors
Nadine G. Rouphael, Lilin Lai, Sonia Tandon, Michele Paine McCullough, Yunchuan Kong, Sarah Kabbani, Muktha S. Natrajan, Yongxian Xu, Yexun Zhu, Dongli Wang, Jesse O'Shea, Amy Sherman, Tianwei Yu, Sebastian Henry, Devin McAllister, Daniel Stadlbauer, Surender Khurana, Hana Golding, Florian Krammer, Mark J. Mulligan, Mark R. Prausnitz
Tags
influenza vaccine
microneedle patches
immunogenicity
safety
clinical trial
humoral response
cellular response

Related Publications

Explore these studies to deepen your understanding of the subject.

Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b/2 study in South African adults (COV005)
Medicine and Health

Efficacy of primary series AZD1222 (ChAdOx1 nCoV-19) vaccination against SARS-CoV-2 variants of concern: Final analysis of a randomized, placebo-controlled, phase 1b/2 study in South African adults (COV005)

A. L. Koen, A. Izu, et al.

Does participating in online communities enhance the effectiveness and experience of micro-learning? Evidence from a randomized control trial
Education

Does participating in online communities enhance the effectiveness and experience of micro-learning? Evidence from a randomized control trial

J. Zhu, H. He, et al.

Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment
Health and Fitness

Exploratory analysis of eating- and physical activity-related outcomes from a randomized controlled trial for weight loss maintenance with exercise and liraglutide single or combination treatment

S. B. K. Jensen, C. Janus, et al.

Efficacy of an app-based multimodal lifestyle intervention on body weight in persons with obesity: results from a randomized controlled trial
Health and Fitness

Efficacy of an app-based multimodal lifestyle intervention on body weight in persons with obesity: results from a randomized controlled trial

K. Gemesi, S. Winkler, et al.

Listen, Learn & Level Up
Over 10,000 hours of research content in 25+ fields, available in 12+ languages.
No more digging through PDFs, just hit play and absorb the world's latest research in your language, on your time.
listen to research audio papers with researchbunny