Medicine and HealthFrontiers in Cellular Neuroscience
Human brain organoids: an innovative model for neurological disorder research and therapy
H. Li, J. Zhu, et al.
Human brain organoids (hBOs) are redefining brain research by recapitulating cellular diversity, architecture, and connectivity to advance diagnosis and treatment of Alzheimer’s, Parkinson’s, and related disorders. Combining patient-derived iPSCs with gene-editing enables precise mechanistic studies and scalable drug screening; this review, conducted by the authors listed in the <Authors> tag, outlines advantages, limitations, and therapeutic potential.
Related Publications
Explore these studies to deepen your understanding
Adjacent work that informs or extends this paper's methodology and findings.
Medicine and Health
Reliability of high-quantity human brain organoids for modeling microcephaly, glioma invasion and drug screening
A. Ramani, G. Pasquini, et al.
Psychology
Brain markers predicting response to cognitive-behavioral therapy for social anxiety disorder: an independent replication of Whitfield-Gabrieli et al. 2015
Y. K. Ashar, J. Clark, et al.
Medicine and Health
Human Brain Organoids-on-Chip: Advances, Challenges, and Perspectives for Preclinical Applications
H. Castiglione, P. Vigneron, et al.
Psychology
Neuroimaging the effects of smartphone (over-)use on brain function and structure—a review on the current state of MRI-based findings and a roadmap for future research
C. Montag and B. Becker
