This study conducted an independent replication of a previously published marker predicting treatment response to cognitive-behavioral therapy (CBT) for social anxiety disorder (SAD) using resting-state fMRI amygdala connectivity. The replication, using a similar dataset, found that the original model positively predicted treatment outcomes, but with marginal statistical significance (permutation test p = 0.1). The effect size was substantially smaller in the replication dataset (2% variance explained) compared to the original report (21%). While amygdala function may predict treatment response, models explaining substantial variance in independent datasets are needed for clinical applications.
Publisher
Translational Psychiatry
Published On
Jan 31, 2021
Authors
Yoni K Ashar, Joseph Clark, Faith M Gunning, Philippe Goldin, James J Gross, Tor D Wager
Tags
cognitive-behavioral therapy
social anxiety disorder
amygdala connectivity
treatment response
replication study
fMRI
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