Psychology

Brain markers predicting response to cognitive-behavioral therapy for social anxiety disorder: an independent replication of Whitfield-Gabrieli et al. 2015

Y. K. Ashar, J. Clark, et al.

Discover groundbreaking research conducted by Yoni K Ashar and colleagues, revealing insights into the predictive power of amygdala connectivity for treatment response to cognitive-behavioral therapy in social anxiety disorder. While the original model showed promise, this independent replication highlights the need for greater explanatory strength in clinical applications.

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Abstract

This study conducted an independent replication of a previously published marker predicting treatment response to cognitive-behavioral therapy (CBT) for social anxiety disorder (SAD) using resting-state fMRI amygdala connectivity. The replication, using a similar dataset, found that the original model positively predicted treatment outcomes, but with marginal statistical significance (permutation test p = 0.1). The effect size was substantially smaller in the replication dataset (2% variance explained) compared to the original report (21%). While amygdala function may predict treatment response, models explaining substantial variance in independent datasets are needed for clinical applications.

Publisher

Translational Psychiatry

Published On

Jan 31, 2021

Authors

Yoni K Ashar, Joseph Clark, Faith M Gunning, Philippe Goldin, James J Gross, Tor D Wager

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