Medicine and Health

Human brain organoids: an innovative model for neurological disorder research and therapy

H. Li, J. Zhu, et al.

Human brain organoids (hBOs) are redefining brain research by recapitulating cellular diversity, architecture, and connectivity to advance diagnosis and treatment of Alzheimer’s, Parkinson’s, and related disorders. Combining patient-derived iPSCs with gene-editing enables precise mechanistic studies and scalable drug screening; this review, conducted by the authors listed in the <Authors> tag, outlines advantages, limitations, and therapeutic potential.

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~3 min • Beginner • English

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