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Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome

Medicine and Health

Gut microbiota-derived tryptamine and phenethylamine impair insulin sensitivity in metabolic syndrome and irritable bowel syndrome

L. Zhai, H. Xiao, et al.

This groundbreaking research reveals a direct link between *Ruminococcus gnavus*-derived compounds, tryptamine and phenethylamine, and insulin resistance in individuals with IBS and type 2 diabetes. Conducted by an expert team from Hong Kong Baptist University and Rutgers University, these findings open new avenues for potential therapeutic interventions targeting the TAAR1 signaling axis.

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