Medicine and Health

Gut Microbiota Contribution to Weight-Independent Glycemic Improvements after Gastric Bypass Surgery

M. K. Hankir, P. Kovatcheva-datchary, et al.

Discover how Roux-en-Y gastric bypass surgery not only aids in weight loss but also enhances glycemic control through gut microbiota changes. In a study by Mohammed K Hankir and colleagues, significant correlations were found between specific gut bacteria and improved glucose tolerance, unveiling new insights into microbiota-host interactions.

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Abstract

Roux-en-Y gastric bypass surgery (RYGB) improves glycemic control in severely obese individuals beyond weight loss effects. This study investigated gut microbiota's role using a preclinical RYGB model. 16S rRNA sequencing revealed altered fecal microbiota composition in RYGB-treated Zucker fatty rats, including lower Erysipelotrichaceae. This species correlated with glycemic control in RYGB rats, with Longibaculum muris showing positive correlation with glucose intolerance. Fecal microbiota transplant partially transferred improved glucose tolerance from RYGB rats to germfree mice. L. muris supplementation further improved glucose tolerance in RYGB recipients. These findings indicate gut microbiota contributes to weight-loss independent glycemic improvements after RYGB, highlighting the complexity of microbiota-host interactions.

Publisher

Microbiology Spectrum

Published On

Apr 06, 2023

Authors

Mohammed K Hankir, Petia Kovatcheva-Datchary, Rebecca Springer, Annett Hoffmann, Jörg Vogel, Florian Seyfried, Tulika Arora

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