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Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice

Medicine and Health

Gut microbiota changes require vagus nerve integrity to promote depressive-like behaviors in mice

E. Siopi, M. Galerne, et al.

This exciting study by Eleni Siopi and colleagues uncovers how the vagus nerve mediates stress-induced changes in the gut microbiome, influencing brain plasticity and behaviors associated with depression in mice. Their findings reveal that the vagus nerve's role is crucial in these processes, highlighting the gut-brain connection's impact on mental health.

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Playback language: English
Abstract
This study investigated the role of the vagus nerve (VN) in mediating the effects of stress-induced gut microbiome (GM) changes on hippocampal plasticity and depressive-like behaviors in mice. Mice were subjected to unpredictable chronic mild stress (UCMS), and their fecal microbiota was transferred to healthy recipient mice. Some recipients underwent subdiaphragmatic vagotomy (Vx) before transplantation. Results showed that UCMS-derived GM activated the VN, altered neurotransmission pathways, reduced hippocampal neurogenesis, and induced neuroinflammation. Remarkably, Vx prevented these effects, indicating the VN's necessity in mediating GM's influence on brain function and behavior.
Publisher
Molecular Psychiatry
Published On
May 02, 2023
Authors
Eleni Siopi, Mathieu Galerne, Manon Rivagorda, Soham Saha, Carine Moigneu, Stéphanie Moriceau, Mathilde Bigot, Franck Oury, Pierre-Marie Lledo
Tags
vagus nerve
gut microbiome
hippocampal plasticity
depressive behaviors
neuroinflammation
chronic stress
neurogenesis
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