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Abstract
This study investigated the mechanism by which Lycium barbarum polysaccharide (LBP) alleviates rheumatoid arthritis (RA) in a rat model, focusing on its effects on gut microbiota. LBP significantly altered gut microbiota composition, reducing the abundance of Lachnospiraceae_NK4A136_group and uncultured_bacterium_f_Ruminococcaceae, while increasing Romboutsia, Lactobacillus, Dubosiella, and Faecalibaculum. This shift correlated with decreased expression of RA-related genes (Dpep3, Gstm6, Slc27a2, Col11a2, Sycp2, SNORA22, Tnni1, Gpnmb, Mypn, and Acsl6) due to DNA hypermethylation, possibly mediated by increased S-adenosyl methionine (SAM) levels. The findings suggest LBP alleviates RA by modulating gut microbiota to influence host gene expression.
Publisher
npj Science of Food
Published On
Authors
Wenjia Lai, Chunyan Wang, Renfa Lai, Xichun Peng, Jianming Luo
Tags
Lycium barbarum
polysaccharide
rheumatoid arthritis
gut microbiota
gene expression
DNA methylation
S-adenosyl methionine

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