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Abstract
This study uses nationwide health records and genealogies from Denmark and Sweden (n=17 million) to investigate the genetic and environmental contributions to the comorbidity between six mental disorders and 15 cardiometabolic disorders. Genetic factors contributed about 50% to the comorbidity of schizophrenia, affective disorders, and autism spectrum disorder with cardiometabolic disorders, while environmental factors were the main driver for attention-deficit/hyperactivity disorder and anorexia nervosa comorbidity with cardiometabolic disorders. The findings provide causal insights to guide clinical and scientific initiatives.
Publisher
Nature Communications
Published On
Jun 13, 2024
Authors
Joeri Meijsen, Kejia Hu, Morten D. Krebs, Georgios Athanasiadis, Sarah Washbrook, Richard Zetterberg, Raquel Nogueira Avelar e Silva, John R. Shorter, Jesper R. Gådin, Jacob Bergstedt, David M. Howard, Weimin Ye, Yi Lu, Unnur A. Valdimarsdóttir, Andrés Ingason, Dorte Helenius, Oleguer Plana-Ripoll, John J. McGrath, Nadia Micali, Ole A. Andreassen, Thomas M. Werge, Fang Fang, Alfonso Buil
Tags
mental disorders
cardiometabolic disorders
genetic factors
environmental factors
comorbidity
Denmark
Sweden

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